News Digest 19.04.2024 — 22.04.2024
Regulators
Putin gave instructions on the development of medical science and education
Russian President Vladimir Putin has prepared a number of instructions relating to science, intellectual activity and education in the medical field. In particular, he pointed out the need to expand the network of National Medical Research Centers, develop international cooperation and scientific internships for students, and establish non-financial support measures for the creation of private research centers (SRCs) that ensure the production and implementation of high-tech products.
At the Future Technologies Forum in February 2024, Putin made several statements regarding the state of the healthcare industry. Then he announced the creation of a new national project for the development of modern technologies in healthcare, plans to increase funding for innovative developments in medicine, and specified the rules for payments for the use of intellectual property. These theses are reflected in the published list of instructions.
Thus, before December 2024, the government needs to propose changes to the legislation of the Russian Federation, regulating the clarification of the rules and the definition of a unified methodology for calculating the amount of remuneration for the authors of the results of intellectual activity that are breakthrough scientific or technical solutions. By July 1, 2024, it is also necessary to ensure the expansion of the National Medical Research Center network and provide funding for the operation of such centers.
“To ensure the development of international cooperation in the field of medical science and education, including by increasing the volume of joint scientific research and expanding scientific internship programs for Russian and foreign students, graduate students, scientists and specialists,” one of the instructions says. The report must be submitted by September 1.
The Government of the Russian Federation should consider supporting scientific research in the field of molecular diagnostics of allergies and the development of vaccines using genetic engineering methods and establishing non-financial support measures for the creation and development of private research centers that will be able to work in the field of high-tech production, including in the field of biology and genetics.
By the end of 2024, according to the presidential order, it is necessary to develop and begin implementation of a number of national projects: the development of modern health saving technologies, increasing the effectiveness of preventive programs for the early detection of conditions, diseases and risk factors for their development, the transition to personalized, predictive and preventive medicine, the development of regenerative medicine and the development of biotechnological, high-tech and radiopharmaceuticals, including those specially manufactured for a specific patient.
Among the national projects to be developed are the introduction into practical healthcare of domestic drugs (including radiopharmaceuticals), medical devices and biomedical cellular products, including those created using cellular technologies, the development of individual nutrition programs, the introduction of biomedical technologies (bioprinting and active longevity), remote monitoring of population health indicators and implementation of advanced digital and medical technologies, including those created on the basis of artificial intelligence (AI) technologies. Reports must be submitted by October 1, 2024 and April 15, 2025.
It is necessary to increase the amount of support for the development of innovative medical technologies and products through the annual allocation of additional allocations from the federal budget. Before May 1, 2024, it is necessary to ensure the development and implementation of test systems for the needs of primary healthcare to determine the causative agents of the most common infectious diseases (up to 100 diseases), as well as the development of technologies for the development of drugs based on matrix ribonucleic acids, including drugs for the treatment of cancer diseases.
“Ensure the development and implementation of a mechanism for the planned renewal of the material and technical base of medical and scientific organizations subordinate to federal executive authorities that provide high-tech medical care, as well as financial support for the use of such a mechanism,” the list says.
It is important to analyze the effectiveness of the implementation of higher education educational programs by scientific organizations. If necessary, the responsible authorities should submit a proposal to disseminate positive experience in program implementation.
Together with the state corporation Rosatom, the government in 2025, during the Future Technologies Forum, needs to consider issues on the creation and implementation of new generation materials for use in various sectors of the economy. Together with the Russian Foreign Ministry, the authorities need to develop long-term joint cooperation between specialized scientific centers of the BRICS countries in the field of development of nuclear medicine, including the development and implementation of radiopharmaceutical drugs.
Putin also gave a number of instructions to the Russian Ministry of Health. In particular, the department, together with the Ministry of Construction, needs to consider the issue of starting construction in 2024 of the production of gene therapy drugs on the basis of the Russian National Research Medical University named after. N.I. Pirogov. The heads of the ministries, Mikhail Murashko and Irek Faizullin, were appointed responsible. The report must be submitted by September 1, 2024.
Together with the Moscow government, the Ministry of Health must, by June 1, consider the creation of centralized AI services that can be used by medical organizations across the country to conduct diagnostic studies, taking into account the developments and technological capabilities of Moscow. In addition to Murashko, Moscow Mayor Sergei Sobyanin has been appointed responsible for the execution of the order.
At the beginning of March 2024, Vladimir Putin, in his message to the Federal Assembly, announced the national project “Personnel” and a number of measures for the training of medical and pharmaceutical workers. He spoke about the modernization of secondary, higher education and science by 2030. Read more in the review of the theses of the head of state prepared by Vademecum.
Market news
The production of medical gloves will be opened in the Kaliningrad region for 169 million rubles
On April 10, 2024, the Ministry of Industry and Trade of Russia entered into a special investment contract (SPIC 2.0) with the Nitriland company to introduce technology for the production of latex medical examination and sterile gloves in Gvardeysk, Kaliningrad region. The contract is valid until the end of 2030, the volume of investments will be 169.234 million rubles.
According to the SPIC, by 2025, the investor must begin mass production of medical examination gloves - latex, powder-free, sterile and nitrile, powder-free, non-sterile, disposable. Sterile surgical gloves made from natural and synthetic latex should be produced at the company’s plant starting in 2023.
The planned volumes of produced and sold products are estimated at almost 3.448 billion rubles.
The application of the Kaliningrad NJSC Nitriland for the implementation of technology for the production of medical products from natural and synthetic latex, including medical gloves (diagnostic (examination) latex powder-free sterile disposable and nitrile powder-free non-sterile), was considered on February 8, 2023 at a meeting of the Commission for the conclusion, amendment and termination of Ministry of Industry and Trade. Then the commission recommended concluding a SPIC with the company.
Nitriland began implementing individual technological operations - packaging, sterilization, preparation for sale of finished gloves - from the second quarter of 2023, and plans to implement full localization of production from the first quarter of 2025. After 2026, early cessation of production is possible.
The planned production volume of gloves at the plant in the Kaliningrad region was initially estimated at 263 million pairs, and the volume of product sales was at the level of 3 billion rubles. In 2023, the company planned to create 92 jobs, and after the organization of full-scale production in 2025, their number will not change.
According to SPARK-Interfax, NJSC Nitriland was registered in 2021 in Gvardeysk, Kaliningrad region. The founders are not disclosed. There is no data on revenue in 2023; the loss amounted to 1.35 million rubles.
Modern equipment has arrived at the Danilovskaya Central District Hospital of the Yaroslavl Region
The Federal Service for Surveillance in Healthcare constantly monitors the implementation of the National Healthcare Project in all regions of the country. According to the Territorial Authority of Roszdravnadzor for the Yaroslavl Region, thanks to the federal program “Modernization of the primary health care system”, the arsenal of the clinic of the State Budgetary Healthcare Institution YAO “Danilovskaya Central District Hospital” was replenished with modern equipment. The main acquisition was a digital X-ray machine, worth 13.5 million rubles. Medical equipment has already arrived at the Central District Hospital and is used in the examination and medical examination of residents of the area.
Source: https://t.me/roszdravnadzor_official/2445
Other
Sechenov University has developed the first visually guided urinary catheter in Russia
Employees of the Production Laboratory of Innovative Engineering Solutions of the Institute of Urology and Human Reproductive Health of the First Moscow State Medical University, under the leadership of Professor Magomed Gazimiev, developed an innovative urinary catheter Visus MG. It allows you to empty the bladder not blindly, but under visual control, and also allows you to diagnose urinary tract diseases. Unlike traditional catheterization of the bladder in patients with acute urinary retention, the effectiveness of using this device is almost 100%. Clinical studies of the effectiveness and safety of the medical product are currently underway. The device was developed jointly with the laboratory's industrial partner, Minimally Invasive Technologies, LLC (“MIT”).
Artificial intelligence discovered cerebral artery stenosis
Scientific group of specialists from Moscow State University. M.V. Lomonosov, Moscow Polytechnic University and Gammamed-Soft LLC have developed a unique algorithm that uses artificial intelligence to automatically detect areas of narrowing of the cerebral arteries. As reported by the press service of the Moscow Polytechnic University, the assessment of blood vessels was carried out on the basis of computed tomographic angiography (CTA) data.
Source: https://nauka.tass.ru/nauka/20542511
A breakthrough in the treatment of aortic aneurysm. Scientists from Sechenov University were the first in the world to successfully implant a vascular prosthesis with petals of the sinuses of the aortic root into a patient
Young scientists of the First Moscow State Medical University named after. I.M. Sechenov of the Russian Ministry of Health developed a vascular prosthesis with petals of the sinuses of the aortic root. The development is already being used in practice - the prosthesis has been successfully implanted in the first patient.
The aorta is the largest blood vessel in the body, and if it is in danger of rupture or expansion, a person's life is at risk. In this case, it is replaced with a prosthesis. However, according to Maxim Tkachev, an assistant at the Department of Cardiovascular Surgery at Sechenov University, standard prostheses do not have the flexibility and elasticity characteristic of a healthy aorta; in addition, after prosthetics, the patient is forced to take the blood-thinning drug warfarin for life.
The innovative development of scientists from Sechenov University is a reliable and effective replacement for a damaged aorta and aortic valve; it allows patients to return to a full and high-quality life without lifelong drug support.
Experimental samples of the prosthesis developed at Sechenov University were produced with the support of the JSC Medtechnoproekt enterprise; industrial production will be established in the near future.
Scientists have created a neural network dataset that identifies eye diseases that lead to blindness
The Russian Ministry of Education and Science told Gazeta.Ru about this; the work was carried out with financial support under the Priority 2030 program.
Eye diseases and vision disorders are widespread and too often go untreated. Ultimately, this can lead to the development of blindness, so it is important to diagnose them in time. Usually, the OCT method is used for this, which allows you to visualize the layers of the retina with histological accuracy. Scientists collected images of various pathologies into one dataset for training neural networks. As a result, they ended up with the second largest such dataset in the world and the first in terms of the number of diseases.
“The dataset consists of OCT recordings from patients with pathologies such as age-related macular degeneration, diabetic macular edema, epiretinal membrane changes, retinal artery or vein occlusion, and vitreomacular interface disease. This is the first dataset of OCT images in the world with so many diseases. We hope that it will help build a decision support system more efficiently and accurately, and that other researchers will use our database to build more complex networks,” Vasily Borisov, associate professor of the Department of Information Technologies and Control Systems at UrFU, told Gazeta.Ru.
The database is registered, patented and available for download. It has already been tested on two neural networks. “For example, for age-related macular degeneration, we received a high accuracy of diagnosis - 97%. For retinal vein occlusion - 60–65%. The percentage of accuracy is determined, among other things, by the prevalence of the disease - the more cases there are for training the neural network, the higher the percentage of diagnosis accuracy. We will continue to work on this. We will try to expand the database regarding rare diseases, including hereditary retinal dystrophy, retinopathy of prematurity and other conditions that threaten vision,” Borisov explained.
The new database will help doctors quickly determine whether the eye condition is normal or not, which will allow them to begin treatment faster.
Source: https://www.pharmcontrol.ru/news_medic.php?id=121268
News
